Article
Mouse strains for the ubiquitous or conditional overexpression of the Flii gene.
Genesis (New York, N.Y. : 2000) - 1 Aug 2011
Thomsen Nicole, Chappell Anna, Ali Radiya G, Jones Tamsin, Adams Damian H, Matthaei Klaus I, Campbell Hugh D, Cowin Allison J, Arkell Ruth M
Abstract excerpt
The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and humans Flii expression increases with age and amelioration of FLII activity represents a possible therapeutic strategy for improved wound healing in humans. Despite analysis...
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