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Article

Effect of mitochondrial tRNA(Lys) mutation on the clinical and biochemical characteristics of Chinese essential hypertensive subjects.

Biochemical and biophysical research communications - 28 Nov 2014

Lu Yan, Xiao Tiehui, Zhang Feng, Chen Yanming, Liu Yuqi, Li Yang, Chen Yun Dai, Li Zongbin, Guan Minxin

Abstract excerpt

Mitochondrial dysfunction has been potentially implicated in both human and experimental hypertension. We performed the mutational analysis of tRNA(Lys) gene by PCR amplification and subsequent sequence analysis of the PCR fragments from 990 Chinese essential hypertensive subjects. We also made a comparative analysis of the collected data of the essential hypertension subjects who carried tRNA(Lys) mutation and...

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Identifiers

PMID: 25451269
DOI: 10.1016/j.bbrc.2014.10.089

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