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Article

Interleukin-19 increases angiogenesis in ischemic hind limbs by direct effects on both endothelial cells and macrophage polarization.

Journal of molecular and cellular cardiology - 1 Feb 2015

Richards James, Gabunia Khatuna, Kelemen Sheri E, Kako Farah, Choi Eric T, Autieri Michael V

Abstract excerpt

Hypoxia in ischemic limbs typically initiates angiogenic and inflammatory factors to promote angiogenesis in attempt to restore perfusion. There is a gap in our knowledge concerning the role of anti-inflammatory interleukins in angiogenesis, macrophage polarization, and endothelial cell activation. Interleukin-19 is a unique anti-inflammatory Th2 cytokine that promotes angiogenic effects in cultured endothelial...

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Identifiers

PMID: 25450612
DOI: 10.1016/j.yjmcc.2014.11.002
PMCID: PMC4301995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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