Article
Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19-/-×Ldlr-/- Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R).
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2018
Ray Mitali, Gabunia Khatuna, Vrakas Christine N, Herman Allison B, Kako Farah, Kelemen Sheri E, Grisanti Laurel A, Autieri Michael V
Abstract excerpt
OBJECTIVE: To test the hypothesis that loss of IL-19 (interleukin-19) exacerbates atherosclerosis. APPROACH AND RESULTS: Il19-/- mice were crossed into Ldlr-/- (low-density lipoprotein receptor knock out) mice. Double knockout (dKO) mice had increased plaque burden in aortic arch and root compared with Ldlr-/- controls after 14 weeks of high-fat diet (HFD). dKO mice injected with 10 ng/g per day rmIL-19 had...
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