Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vinculin functions as regulator of chondrogenesis.

The Journal of biological chemistry - 4 May 2012

Koshimizu Takao, Kawai Masanobu, Kondou Hiroki, Tachikawa Kanako, Sakai Norio, Ozono Keiichi, Michigami Toshimi

Abstract excerpt

To identify the genes involved in chondrocytic differentiation, we applied gene trap mutagenesis to a murine mesenchymal chondrogenic cell line ATDC5 and isolated a clone in which the gene encoding vinculin was trapped. The trapped allele was assumed to express a fusion protein containing a truncated vinculin lacking the tail domain and the geo product derived from the trap vector. The truncated vinculin was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggrecans
Share to Chondrocytes
Share to Chondrogenesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Collagen Type II

Share to Collagen Type X

Share to Organ Culture Techniques

Share to SOX9 Transcription Factor

Share to Vinculin

Source

Open in PubMed Open full text

Identifiers

PMID: 22416133
DOI: 10.1074/jbc.M111.308072
PMCID: PMC3346098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vinculin functions as regulator of chondrogenesis.PMID 22416133Read ↗

In situ mechanotransduction via vinculin regulates stem cell differentiationSemantic proximity Read ↗

Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis.Semantic proximity Read ↗

Rab23 regulates differentiation of ATDC5 chondroprogenitor cells.Semantic proximity Read ↗

Focal adhesion protein vinculin inhibits Mef2c-driven sclerostin expression in osteocytes to promote bone formation in miceSemantic proximity Read ↗

Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.Semantic proximity Read ↗

Vinculin gene is non-essential in Drosophila melanogaster.Semantic proximity Read ↗

Role of vinculin in regulating focal adhesion turnover.Semantic proximity Read ↗

Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner.Semantic proximity Read ↗

Vinculin E29R mutation changes cellular mechanics.Semantic proximity Read ↗

Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin.Semantic proximity Read ↗

Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.Semantic proximity Read ↗

Mechano-coupling and regulation of contractility by the vinculin tail domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.