Article
CREM variant rs17583959 conferred susceptibility to T1D risk in the Tunisian families.
Immunology letters - 1 Jan 2017
Zouidi Ferjani, Bouzid D, Fourati H, Fakhfakh R, Kammoun T, Hachicha M, Penha-Gonçalves C, Masmoudi H
Abstract excerpt
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of insulin-producing pancreatic β-cells by autoreactive T cells. Studies in animal models, such as the non-obese diabetic (NOD) mouse reveal that this disease is under the control of several genes that encode molecules implicated in regulation of transcription factors and in T cell activation. In order to underline the role...
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