Article
Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy.
Journal of cellular physiology - 1 Nov 2014
Feldman Arthur M, Begay Rene L, Knezevic Tijana, Myers Valerie D, Slavov Dobromir B, Zhu Weizhong, Gowan Katherine, Graw Sharon L, Jones Kenneth L, Tilley Douglas G, Coleman Ryan C, Walinsky Paul, Cheung Joseph Y, Mestroni Luisa, Khalili Kamel, Taylor Mathew R G
Abstract excerpt
The most common cause of dilated cardiomyopathy and heart failure (HF) is ischemic heart disease; however, in a third of all patients the cause remains undefined and patients are diagnosed as having idiopathic dilated cardiomyopathy (IDC). Recent studies suggest that many patients with IDC have a family history of HF and rare genetic variants in over 35 genes have been shown to be causative of disease. We...
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