Article

Novel combination of TTN and CTNNA3 Pathogenic variant leading to Familial Dilated Cardiomyopathy: From acute heart failure to subclinical phenotypes.

2025-10-28

Abstract excerpt

Background Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure and the most common indication for cardiac transplantation in young adults. The clinical spectrum of DCM is heterogeneous, ranging from asymptomatic left ventricular dysfunction to advanced heart failure, arrhythmias, and sudden cardiac death. Methods Whole-exome sequencing (WES) was performed on germline DNA of the index case fo...

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Literature Corpus work: d08102b4-969f-50dc-8e7d-9c9ac66fc878
DOI: 10.12688/f1000research.170824.1

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