Article
Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018
Lipper Colin H, Karmi Ola, Sohn Yang Sung, Darash-Yahana Merav, Lammert Heiko, Song Luhua, Liu Amy, Mittler Ron, Nechushtai Rachel, Onuchic José N, Jennings Patricia A
Abstract excerpt
The NEET family is a relatively new class of three related [2Fe-2S] proteins (CISD1-3), important in human health and disease. While there has been growing interest in the homodimeric gene products of CISD1 (mitoNEET) and CISD2 (NAF-1), the importance of the inner mitochondrial CISD3 protein has only recently been recognized in cancer. The CISD3 gene encodes for a monomeric protein that contains two [2Fe-2S]...
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