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Article

The role of proline substitutions within flexible regions on thermostability of luciferase.

Biochimica et biophysica acta - 1 Jan 2015

Yu Haoran, Zhao Yang, Guo Chao, Gan Yiru, Huang He

Abstract excerpt

Improving the stability of firefly luciferase has been a critical issue for its wider industrial applications. Studies about hyperthermophile proteins show that flexibility could be an effective indicator to find out weak spots to engineering thermostability of proteins. However, the relationship among flexibility, activity and stability in most of proteins is unclear. Proline is the most rigid residue and can be...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25448017
DOI: 10.1016/j.bbapap.2014.10.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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