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Steroid hormone imbalance drives macrophage infiltration and <i>Spp1</i> /osteopontin <sup>+</sup> foam cell differentiation in the prostate

2022-12-15

Abstract excerpt

Benign Prostatic Hyperplasia (BPH) occurs progressively with aging in men and drives deteriorating symptoms collectively known as Lower Urinary Tract Symptoms (LUTS). Age associated changes in circulating steroid hormones, and prostate inflammation have been postulated in the etiology of BPH/LUTS. The link between hormones and inflammation in the development of BPH/LUTS is conflicting because they may occur indepe...

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Identifiers and source

Literature Corpus work
9c29f169-c137-5b48-980a-8f25f0cd271d
DOI
10.1101/2022.12.13.520247
Open publication

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