Article
Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation.
Life sciences - 1 Jan 2015
Chang Hae Yeun, Lee Ha-Na, Kim Wonki, Surh Young-Joon
Abstract excerpt
AIMS: Impaired resolution of acute inflammation results in development of chronic inflammatory disorders such as atherosclerosis, asthma and arthritis. Clearance of apoptotic neutrophils by M2 macrophages, the process termed efferocytosis, is critical for complete resolution of inflammation as it prevents secondary necrosis caused by disgorgement of toxic contents from apoptotic cells in the inflamed site. In the...
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