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Article

High-dose dexamethasone or all-trans-retinoic acid restores the balance of macrophages towards M2 in immune thrombocytopenia.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2017

Feng Q, Xu M, Yu Y Y, Hou Y, Mi X, Sun Y X, Ma S, Zuo X Y, Shao L L, Hou M, Zhang X H, Peng J

Abstract excerpt

Essentials M1/M2 imbalance is involved in many autoimmune diseases, and could be restored. The expressions and functions of M1 and M2 were investigated in an in vitro culture system. A preferred M1 polarization is involved in the pathogenesis of immune thrombocytopenia (ITP). High-dose dexamethasone or all-trans-retinoic acid restores M1/M2 balance in ITP patients. SUMMARY: Background Immune thrombocytopenia...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Purpura, Thrombocytopenic, Idiopathic

Share to T-Lymphocytes, Helper-Inducer

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Source

Identifiers

PMID: 28682499
DOI: 10.1111/jth.13767

Genes

LAG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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