Article
Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype.
Scientific reports - 7 Mar 2017
Xia Haifa, Chen Lin, Liu Hong, Sun Zhipeng, Yang Wen, Yang Yiyi, Cui Shunan, Li Shengnan, Wang Yaxin, Song Limin, Abdelgawad Amro Fayez, Shang You, Yao Shanglong
Abstract excerpt
Recently, a serial of studies have demonstrated that lipid mediators derived from Omega-3 fatty acid docosahexaenoic acid have pro-resolving or anti-inflammatory effects in many inflammatory diseases. Here, we sought to evaluate whether Protectin DX (PDX, an isomer of Protecin D1), a newly identified lipid mediator, could protect mice against sepsis and explore the underling mechanism. Animal model of sepsis was...
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