Article
Inferring fitness landscapes by regression produces biased estimates of epistasis.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2014
Otwinowski Jakub, Plotkin Joshua B
Abstract excerpt
The genotype-fitness map plays a fundamental role in shaping the dynamics of evolution. However, it is difficult to directly measure a fitness landscape in practice, because the number of possible genotypes is astronomical. One approach is to sample as many genotypes as possible, measure their fitnesses, and fit a statistical model of the landscape that includes additive and pairwise interactive effects between...
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