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Article

Twenty years of lesson learning: how does the <i><scp>RET</scp></i> genetic screening test impact the clinical management of medullary thyroid cancer?

2 Dec 2014

Abstract excerpt

OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare disease that can be inherited or sporadic; its pathogenesis is related to activating mutations in the RET gene. DESIGN: This study describes our 20-year experience regarding RET genetic screening in MTC. PATIENTS AND METHODS: We performed RET genetic screening in 1556 subjects, 1007 with an apparently sporadic MTC, 95 with a familial form and 454 relatives of...

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PMID: 25440022
DOI: 10.1111/cen.12686

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Twenty years of lesson learning: how does the <i><scp>RET</scp></i> genetic screening test impact the clinical management of medullary thyroid cancer?PMID 25440022Read ↗

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New insights in the molecular signature of advanced medullary thyroid cancer: evidence of a bad outcome of cases with double <i>RET</i> mutationsSemantic proximity Read ↗

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