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Article

Modifying impact of RET gene haplotypes on medullary thyroid carcinoma clinical course.

Endocrine-related cancer - 1 Apr 2018

Kaczmarek-Ryś Marta, Ziemnicka Katarzyna, Pławski Andrzej, Budny Bartłomiej, Michalak Michał, Hryhorowicz Szymon, Hoppe-Gołębiewska Justyna, Boruń Paweł, Gołąb Monika, Czetwertyńska Małgorzata, Sromek Maria, Szalata Marlena, Ruchała Marek, Słomski Ryszard

Abstract excerpt

The clinical course of medullary thyroid carcinoma (MTC) associated with the MEN2A syndrome as well as of sporadic MTC shows considerable heterogeneity. The disease picture varies not only between the same RET proto-oncogene mutation carriers but also among sporadic MTC patients with no RET germinal mutations, which suggests the involvement of additional modulators of the disease. However, genetic factors...

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Share to Multiple Endocrine Neoplasia Type 2a

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Source

Identifiers

PMID: 29386230
DOI: 10.1530/ERC-17-0452

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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