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Somatic<i>RAS</i>Mutations Occur in a Large Proportion of Sporadic<i>RET</i>-Negative Medullary Thyroid Carcinomas and Extend to a Previously Unidentified Exon

1 Oct 2012

Abstract excerpt

CONTEXT: Medullary thyroid carcinoma (MTC) is characterized by proto-oncogene RET mutations in almost all hereditary cases as well as in more than 40% of sporadic cases. Recently, a high prevalence of RAS mutations was reported in sporadic MTC, suggesting an alternative genetic event in sporadic MTC tumorigenesis. OBJECTIVE: This study aimed to extend this observation by screening somatic mutational status of...

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PMID: 22865907
DOI: 10.1210/jc.2012-2092

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