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Article

New insights in the molecular signature of advanced medullary thyroid cancer: evidence of a bad outcome of cases with double <i>RET</i> mutations

28 Jul 2016

Abstract excerpt

Background The RET proto-oncogene is responsible for the pathogenesis of hereditary (98%) and sporadic (40%) medullary thyroid carcinoma (MTC). In sporadic MTC, somatic RET mutations are associated with a poor prognosis. Objectives We looked at the genetic profile of patients with advanced and metastatic MTC. The correlation between these mutations and outcome was also investigated. Methods 70 patients with...

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PMID: 27468888
DOI: 10.1136/jmedgenet-2016-103833

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