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Article

Piericidin A aggravates Tau pathology in P301S transgenic mice.

PloS one - 1 Jan 2014

Höllerhage Matthias, Deck Roman, De Andrade Anderson, Respondek Gesine, Xu Hong, Rösler Thomas W, Salama Mohamed, Carlsson Thomas, Yamada Elizabeth S, Gad El Hak Seham A, Goedert Michel, Oertel Wolfgang H, Höglinger Günter U

Abstract excerpt

OBJECTIVE: The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyces spp. with global distribution in marine and agricultural habitats. The aim of this...

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Identifiers

PMID: 25437199
DOI: 10.1371/journal.pone.0113557
PMCID: PMC4249965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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