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Article

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy.

Neurobiology of aging - 1 Sept 2012

Santa-Maria Ismael, Diaz-Ruiz Carmen, Ksiezak-Reding Hanna, Chen Alice, Ho Lap, Wang Jun, Pasinetti Giulio Maria

Abstract excerpt

Tauopathies are characterized by progressive neurodegeneration caused by intracellular accumulation of hyperphosphorylated tau protein aggregates in the brain. The present study was designed to test whether a grape seed polyphenolic extract (GSPE) previously shown to inhibit tau protein aggregation in vitro could benefit tau-mediated neuropathology and behavior deficits in JNPL3 transgenic mice expressing a human...

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Identifiers

PMID: 22054871
DOI: 10.1016/j.neurobiolaging.2011.09.027
PMCID: PMC3472512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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