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Cornel Iridoid Glycoside Regulates Modification of Tau and Alleviates Synaptic Abnormalities in Aged P301S Mice.

Current medical science - 1 Dec 2020

Yang Cui-Cui, Luo Yi, Guo Kai-Wen, Zheng Ceng-Ceng, Li Lin, Zhang Lan

Abstract excerpt

Alzheimer's disease (AD), also defined as a tauopathology, is a common neurodegenerative disease. Hyper-phosphorylation, cleavage or truncation, and aggregation of tau contribute to AD. Thus, targeting the post-translational modifications on tau may be a therapeutic strategy to treat AD. This study understood how cornel iridoid glycoside (CIG) affects tau post-translational modifications and synaptic...

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PMID: 33428131
DOI: 10.1007/s11596-020-2285-y

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