Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein.

Molecular medicine reports - 1 Mar 2015

Lan Danmei, Wang Wenzhao, Zhuang Jianhua, Zhao Zhongxin

Abstract excerpt

The aim of the present study was to examine the effects of proteasome inhibitor (PI)‑induced autophagy on PC12 cells overexpressing A53T mutant α‑synuclein (α‑syn) by detecting alterations in the levels of microtubule‑associated protein 1A/1B light chain (LC3)+ autophagosomes and the lysotracker‑positive autolysosomes using immunofluorescence, the expression of LC3‑II using western blot analysis and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PC12 Cells
Share to Adenine
Share to alpha-Synuclein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Cell Death

Share to Leupeptins

Share to Proteasome Inhibitors

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25434876
DOI: 10.3892/mmr.2014.3011
PMCID: PMC4270325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein.PMID 25434876Read ↗

Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells.Semantic proximity Read ↗

Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells.Semantic proximity Read ↗

Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synucleinSemantic proximity Read ↗

Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells.Semantic proximity Read ↗

α-Synuclein reduces acetylserotonin O-methyltransferase mediated melatonin biosynthesis by microtubule-associated protein 1 light chain 3 beta-related degradation pathwaySemantic proximity Read ↗

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y CellsSemantic proximity Read ↗

α-Synuclein Overexpression Induces Lysosomal Dysfunction and Autophagy Impairment in Human Neuroblastoma SH-SY5Y.Semantic proximity Read ↗

Targeted Suppression of Chaperone-Mediated Autophagy by miR-320a Promotes α-Synuclein AggregationSemantic proximity Read ↗

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Semantic proximity Read ↗

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.Semantic proximity Read ↗

α-Synuclein Accumulation in SH-SY5Y Cell Impairs Autophagy in Microglia by Exosomes Overloading MiR-19a-3pSemantic proximity Read ↗

Overexpression of let-7a increases neurotoxicity in a PC12 cell model of Alzheimer's disease via regulating autophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.