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Article

Isocitrate dehydrogenase 1 mutations (IDH1) and p16/CDKN2A copy number change in conventional chondrosarcomas.

Virchows Archiv : an international journal of pathology - 1 Feb 2015

Amary M Fernanda, Ye Hongtao, Forbes Georgina, Damato Stephen, Maggiani Francesca, Pollock Robin, Tirabosco Roberto, Flanagan Adrienne M

Abstract excerpt

To determine whether IDH1 mutations are present in primary and relapsed (local and distal) conventional central chondrosarcomas; and secondly, to assess if loss of p16/CDKN2A is associated with tumour grade progression, 102 tumour samples from 37 patients, including material from presenting and relapse events, were assessed. All wild-type cases for IDH1 R132 substitutions were also tested for IDH2 R172 and R140...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Copy Number Variations

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Share to In Situ Hybridization, Fluorescence

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Source

Open in PubMed Open full text

Identifiers

PMID: 25432631
DOI: 10.1007/s00428-014-1685-4
PMCID: PMC4325180

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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