Article
A genetic model for central chondrosarcoma evolution correlates with patient outcome.
Genome medicine - 30 Aug 2022
Cross William, Lyskjær Iben, Lesluyes Tom, Hargreaves Steven, Strobl Anna-Christina, Davies Christopher, Waise Sara, Hames-Fathi Shadi, Oukrif Dahmane, Ye Hongtao, Amary Fernanda, Tirabosco Roberto, Gerrand Craig, Baker Toby, Barnes David, Steele Christopher, Alexandrov Ludmil, Bond Gareth, Cool Paul, Pillay Nischalan, Van Loo Peter, Flanagan Adrienne M
Abstract excerpt
BACKGROUND: Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presence and absence of IDH1 and IDH2 mutations, and recently, TERT promoter alterations have been reported in around 20% of cases. The effect of these mutations on clinical...
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