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Article

The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake.

American journal of hypertension - 1 Jun 2015

Tapia-Castillo Alejandra, Carvajal Cristian A, Campino Carmen, Hill Caroline, Allende Fidel, Vecchiola Andrea, Carrasco Carmen, Bancalari Rodrigo, Valdivia Carolina, Lagos Carlos, Martinez-Aguayo Alejandro, Garcia Hernan, Aglony Marlene, Baudrand Rene F, Kalergis Alexis M, Michea Luis F, Riedel Claudia A, Fardella Carlos E

Abstract excerpt

BACKGROUND: Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as hemoxigenase-1 (HO-1) or nuclear factor-B (NF-κB), and the expression of neutrophil gelatinase-associated lipocalin (NGAL), a cytokine upregulated upon MR activation. AIM: We evaluated RAC1 expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25430696
DOI: 10.1093/ajh/hpu224

Genes

RAC1
MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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