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Article

CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers.

European journal of drug metabolism and pharmacokinetics - 1 Apr 2016

Xiong Yuqing, Yuan Zhao, Yang Jingzhi, Xia Chunhua, Li Xinhua, Huang Shibo, Zhang Hong, Liu Mingyi

Abstract excerpt

Rupatadine (RUP) is an oral antihistamine and platelet-activating factor antagonist and is shown as the substrate of CYP3A5 and P-gp. The significant interindividual differences of CYP3A5 and P-gp often cause bioavailability differences of some clinical drugs. The present study is aimed to evaluate the effect of genetic polymorphisms of CYP3A5 and MDR1 on RUP pharmacokinetics in healthy male Chinese volunteer...

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PMID: 25427746
DOI: 10.1007/s13318-014-0236-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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