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Article

Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.

Neoplasia (New York, N.Y.) - 1 Nov 2014

Abdel-Fatah Tarek M A, Arora Arvind, Alsubhi Nouf, Agarwal Devika, Moseley Paul M, Perry Christina, Doherty Rachel, Chan Stephen Y T, Green Andrew R, Rakha Emad, Ball Graham, Ellis Ian O, Madhusudan Srinivasan

Abstract excerpt

ATM-Chk2 network is critical for genomic stability, and its deregulation may influence breast cancer pathogenesis. We investigated ATM and Chk2 protein levels in two cohorts [cohort 1 (n = 1650) and cohort 2 (n = 252)]. ATM and Chk2 mRNA expression was evaluated in the Molecular Taxonomy of Breast Cancer International Consortium cohort (n = 1950). Low nuclear ATM protein level was significantly associated with...

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Source

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Identifiers

PMID: 25425972
DOI: 10.1016/j.neo.2014.09.009
PMCID: PMC4240925

Genes

ATM
SMUG1
XRCC1
CDK1
FEN1
MDM2
MIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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