Article
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Breast cancer research : BCR - 17 Apr 2018
Renault Anne-Laure, Mebirouk Noura, Fuhrmann Laetitia, Bataillon Guillaume, Cavaciuti Eve, Le Gal Dorothée, Girard Elodie, Popova Tatiana, La Rosa Philippe, Beauvallet Juana, Eon-Marchais Séverine, Dondon Marie-Gabrielle, d'Enghien Catherine Dubois, Laugé Anthony, Chemlali Walid, Raynal Virginie, Labbé Martine, Bièche Ivan, Baulande Sylvain, Bay Jacques-Olivier, Berthet Pascaline, Caron Olivier, Buecher Bruno, Faivre Laurence, Fresnay Marc, Gauthier-Villars Marion, Gesta Paul, Janin Nicolas, Lejeune Sophie, Maugard Christine, Moutton Sébastien, Venat-Bouvet Laurence, Zattara Hélène, Fricker Jean-Pierre, Gladieff Laurence, Coupier Isabelle, Chenevix-Trench Georgia, Hall Janet, Vincent-Salomon Anne, Stoppa-Lyonnet Dominique, Andrieu Nadine, Lesueur Fabienne
Abstract excerpt
BACKGROUND: The ataxia telangiectasia mutated (ATM) gene is a moderate-risk breast cancer susceptibility gene; germline loss-of-function variants are found in up to 3% of hereditary breast and ovarian cancer (HBOC) families who undergo genetic testing. So far, no clear histopathological and molecular features of breast tumours occurring in ATM deleterious variant carriers have been described, but identification...
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