Article
Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.
PloS one - 1 Jan 2014
Olsen Jeppe A, Balle Thomas, Gajhede Michael, Ahring Philip K, Kastrup Jette S
Abstract excerpt
Despite extensive studies on nicotinic acetylcholine receptors (nAChRs) and homologues, details of acetylcholine binding are not completely resolved. Here, we report the crystal structure of acetylcholine bound to the receptor homologue acetylcholine binding protein from Lymnaea stagnalis. This is the first structure of acetylcholine in a binding pocket containing all five aromatic residues conserved in all...
Topics
- Acetylcholine
- Animals
- Binding Sites
- Carrier Proteins
- Evoked Potentials
- Models, Molecular
- Molecular Conformation
- Mutation
- Neurotransmitter Agents
- Oocytes
- Protein Binding
- Receptors, Nicotinic
- Tumor Suppressor Protein p53