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Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies.

EBioMedicine - 1 Feb 2022

Yuan Shuai, Yu Lili, Gou Wanglong, Wang Lijuan, Sun Jing, Li Doudou, Lu Ying, Cai Xiaxia, Yu Huanling, Yuan Changzheng, Zheng Ju-Sheng, Larsson Susanna C, Theodoratou Evropi, Li Xue

Abstract excerpt

BACKGROUND: Calcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects of serum calcium. METHODS: One-hundred and thirty genetic variants strongly associated with serum calcium levels were used as instrumental variables. A phenome-wide...

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Identifiers

PMID: 35134646
DOI: 10.1016/j.ebiom.2022.103865
PMCID: PMC8844774

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