Article
The risk of nephrolithiasis is causally related to inactive matrix Gla protein, a marker of vitamin K status: a Mendelian randomization study in a Flemish population.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2018
Wei Fang-Fei, Thijs Lutgarde, Zhang Zhen-Yu, Jacobs Lotte, Yang Wen-Yi, Salvi Erika, Citterio Lorena, Cauwenberghs Nicholas, Kuznetsova Tatiana, E A Drummen Nadja, Hara Azusa, Manunta Paolo, Li Yan, Verhamme Peter, Allegaert Karel, Cusi Daniele, Vermeer Cees, Staessen Jan A
Abstract excerpt
Background: Vitamin K (VK)-dependent γ-glutamate carboxylation and serine phosphorylation activate matrix Gla protein (MGP) to a potent locally acting inhibitor of calcification. Nephrolithiasis represents a process of unwanted calcification associated with substantial mortality and high recurrence rates. We hypothesized that the risk of nephrolithiasis increases with VK shortage, as exemplified by higher plasma...
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