Article
Genetically Predicted Lifelong Circulating 25(OH)D Levels are Associated With Serum Calcium Levels and Kidney Stone Risk.
The Journal of clinical endocrinology and metabolism - 17 Feb 2022
Jian Zhongyu, Huang Yu, He Yazhou, Jin Xi, Li Hong, Li Sheyu, Wang Kunjie
Abstract excerpt
OBJECTIVE: To assess whether lifelong higher circulating 25-hydroxyvitamin D [25(OH)D] levels increase serum calcium levels and kidney stone disease (KSD) risk. METHODS: Summary data for KSD were obtained from the UK biobank genome-wide association study (6536 cases and 388 508 controls). We acquired summary data for 25(OH)D from 120 618 Europeans and another large-scale analysis (443 734 Europeans) for primary...
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