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A community computational challenge to predict the activity of pairs of compounds

17 Nov 2014

Abstract excerpt

Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergistic to the most antagonistic, based on gene-expression profiles of...

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PMID: 25419740
DOI: 10.1038/nbt.3052

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