Article
Na/Ca exchange and Ca2+ homeostasis in the pancreatic beta-cell.
Diabetes & metabolism - 1 Dec 2002
Herchuelz A, Diaz-Horta O, van Eylen F
Abstract excerpt
Recent knowledge concerning the Na/Ca exchanger (NCX) in the pancreatic beta-cell is reviewed. The beta-cell expresses various NCX1 splice variants in a species specific pattern (NCX1.3 and 1.7 in the rat, NCX1.2, 1.3 and 1.7 in the mouse), in variable and different proportions. In the rat beta-cell, the exchanger displays a quite high capacity, accounts for about 70% of Ca2+ extrusion and participates to Ca2+...
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