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Article

The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway.

Molecular pharmacology - 1 Mar 2008

Formisano Luigi, Saggese Mariangela, Secondo Agnese, Sirabella Rossana, Vito Pasquale, Valsecchi Valeria, Molinaro Pasquale, Di Renzo Gianfranco, Annunziato Lucio

Abstract excerpt

The proteins NCX1, NCX2, and NCX3 expressed on the plasma membrane of neurons play a crucial role in ionic regulation because they are the major bidirectional system promoting the efflux and influx of Na(+) and Ca(2+) ions. Here, we demonstrate that NCX1 and NCX3 proteins are novel additional tar...

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Identifiers

PMID: 18079274
DOI: 10.1124/mol.107.042549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18079274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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