Article
No Association between the Plasmodium vivax crt-o MS334 or In9pvcrt Polymorphisms and Chloroquine Failure in a Pre-Elimination Clinical Cohort from Malaysia with a Large Clonal Expansion.
Antimicrobial agents and chemotherapy - 18 Jul 2023
Rumaseb Angela, Moraes Barros Roberto R, Sá Juliana M, Juliano Jonathan J, William Timothy, Braima Kamil A, Barber Bridget E, Anstey Nicholas M, Price Ric N, Grigg Matthew J, Marfurt Jutta, Auburn Sarah
Abstract excerpt
Increasing reports of resistance to a frontline malaria blood-stage treatment, chloroquine (CQ), raises concerns for the elimination of Plasmodium vivax. The absence of an effective molecular marker of CQ resistance in P. vivax greatly constrains surveillance of this emerging threat. A recent genetic cross between CQ sensitive (CQS) and CQ resistant (CQR) NIH-1993 strains of P. vivax linked a moderate CQR...
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