Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells.

Asian journal of andrology - 1 Jan 2000

Wang Ying-Hua, Yan Meng, Zhang Xi, Liu Xin-Yu, Ding Yi-Fu, Lai Chong-Ping, Tong Ming-Han, Li Jin-Song

Abstract excerpt

Azoospermia patients who carry a monogenetic mutation that causes meiotic arrest may have their biological child through genetic correction in spermatogonial stem cells (SSCs). However, such therapy for infertility has not been experimentally investigated yet. In this study, a mouse model with an X-linked testis-expressed 11 (TEX11) mutation (Tex11PM/Y) identified in azoospermia patients exhibited meiotic arrest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azoospermia
Share to CRISPR and Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Mutation

Share to Reproductive Biology and Fertility

Share to Sperm and Testicular Function

Share to Spermatogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 33533741
DOI: 10.4103/aja.aja_97_20
PMCID: PMC8577253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells.PMID 33533741Read ↗

Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseasesSemantic proximity Read ↗

The use of spermatogonial stem cells to correct a mutation causing meiotic arrest.Semantic proximity Read ↗

Restore natural fertility of Kitw/Kitwv mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9Semantic proximity Read ↗

Genome Editing in Mouse Spermatogonial Stem Cell Lines Using TALEN and Double-Nicking CRISPR/Cas9Semantic proximity Read ↗

Induced pluripotent stem cell line from a mouse model of human azoospermia with a frameshift mutation Tex11_1260Ins(TT).Semantic proximity Read ↗

ESX1 gene as a potential candidate responsible for male infertility in nonobstructive azoospermia.Semantic proximity Read ↗

Testis electroporation coupled with autophagy inhibitor to treat non-obstructive azoospermiaSemantic proximity Read ↗

Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive AzoospermiaSemantic proximity Read ↗

Identification of pathogenic mutations from nonobstructive azoospermia patients†.Semantic proximity Read ↗

Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermiaSemantic proximity Read ↗

Spermatogonial stem cells: A story of self-renewal and differentiationSemantic proximity Read ↗

Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility RestorationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.