Article
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.
BMC genomics - 18 Nov 2014
Perdigão João, Silva Hugo, Machado Diana, Macedo Rita, Maltez Fernando, Silva Carla, Jordao Luisa, Couto Isabel, Mallard Kim, Coll Francesc, Hill-Cawthorne Grant A, McNerney Ruth, Pain Arnab, Clark Taane G, Viveiros Miguel, Portugal Isabel
Abstract excerpt
BACKGROUND: Multidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) presents a challenge to disease control and elimination goals. In Lisbon, Portugal, specific and successful XDR-TB strains have been found in circulation for almost two decades. RESULTS: In the present study we have genotyped and sequenced the genomes of 56 Mycobacterium tuberculosis isolates recovered mostly from Lisbon. The...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Chromosome Mapping
- Computational Biology
- Drug Resistance, Multiple, Bacterial
- Evolution, Molecular
- Genetic Loci
- Genetic Variation
- Genome, Bacterial