Article
Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal.
The Journal of antimicrobial chemotherapy - 1 Feb 2010
Perdigão João, Macedo Rita, Malaquias Ana, Ferreira Ana, Brum Laura, Portugal Isabel
Abstract excerpt
OBJECTIVES: Extensively drug-resistant (XDR) tuberculosis (TB) threatens the global control of TB worldwide. Lisbon has a high XDR-TB rate [50% of the multidrug-resistant tuberculosis (MDR-TB)], which is mainly associated with Lisboa family strains. Few studies have addressed the identification of mutations associated with resistance to second-line injectable drugs, and the relative frequency of such mutations...
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