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Human expandable pancreatic progenitor–derived β cells ameliorate diabetes

23 Feb 2022

Abstract excerpt

An unlimited source of human pancreatic β cells is in high demand. Even with recent advances in pancreatic differentiation from human pluripotent stem cells, major hurdles remain in large-scale and cost-effective production of functional β cells. Here, through chemical screening, we demonstrate that the bromodomain and extraterminal domain (BET) inhibitor I-BET151 can robustly promote the expansion of PDX1 +...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35196077
DOI: 10.1126/sciadv.abk1826

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