Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells.

Molecular oncology - 1 Feb 2020

Pérez-Moreno Pablo, Indo Sebastián, Niechi Ignacio, Huerta Hernán, Cabello Pablo, Jara Lilian, Aguayo Francisco, Varas-Godoy Manuel, Burzio Verónica A, Tapia Julio C

Abstract excerpt

Endothelin-1 is a mitogenic peptide that activates several proliferation, survival, and invasiveness pathways. The effects of endothelin-1 rely on its activation by endothelin-converting enzyme-1 (ECE1), which is expressed as four isoforms with different cytoplasmic N termini. Recently, isoform ECE1c has been suggested to have a role in cancer aggressiveness. The N terminus of ECE1c is phosphorylated by protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Casein Kinase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Naphthyridines

Share to Neoplastic Stem Cells

Share to Phenazines

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 31788944
DOI: 10.1002/1878-0261.12609
PMCID: PMC6998658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells.PMID 31788944Read ↗

NEK8 regulates colorectal cancer progression via phosphorylating MYCSemantic proximity Read ↗

Pan-cancer analysis of the prognostic and immunotherapeutic values of exostosin-1Semantic proximity Read ↗

Functional Roles of SPINK1 in Cancers.Semantic proximity Read ↗

ENC1 Facilitates Colorectal Carcinoma Tumorigenesis and Metastasis via JAK2/STAT5/AKT Axis-Mediated Epithelial Mesenchymal Transition and StemnessSemantic proximity Read ↗

Mechanisms Underlying Cancer Growth and Apoptosis by DEK Overexpression in Colorectal CancerSemantic proximity Read ↗

EPLIN, a Putative Tumour Suppressor in Colorectal Cancer, Implications in Drug ResistanceSemantic proximity Read ↗

Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.Semantic proximity Read ↗

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.Semantic proximity Read ↗

UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal TransitionSemantic proximity Read ↗

DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancerSemantic proximity Read ↗

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.Semantic proximity Read ↗

KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.