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Article

Influence of Atg5 mutation in SLE depends on functional IL-10 genotype.

PloS one - 1 Jan 2013

López Patricia, Alonso-Pérez Elisa, Rodríguez-Carrio Javier, Suárez Ana

Abstract excerpt

Increasing evidence supports the involvement of autophagy in the etiopathology of autoimmune diseases. Despite the identification of autophagy-related protein (Atg)-5 as one of the susceptibility loci in systemic Lupus erythematosus (SLE), the consequences of the carriage of these mutations for patients remain unclear. The present work analyzed the association of Atg5 rs573775 single nucleotide polymorphism (SNP)...

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Identifiers

PMID: 24205307
DOI: 10.1371/journal.pone.0078756
PMCID: PMC3799636

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