Article
Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.
PloS one - 1 Jan 2014
Lai Courteney K, Moon Yeonsook, Kuchenbauer Florian, Starzcynowski Daniel T, Argiropoulos Bob, Yung Eric, Beer Philip, Schwarzer Adrian, Sharma Amit, Park Gyeongsin, Leung Malina, Lin Grace, Vollett Sarah, Fung Stephen, Eaves Connie J, Karsan Aly, Weng Andrew P, Humphries R Keith, Heuser Michael
Abstract excerpt
Extensive molecular profiling of leukemias and preleukemic diseases has revealed that distinct clinical entities, like acute myeloid (AML) and T-lymphoblastic leukemia (T-ALL), share similar pathogenetic mutations. It is not well understood how the cell of origin, accompanying mutations, extracellular signals or structural differences in a mutated gene determine the phenotypic identity of leukemias. We dissected...
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