Article
The molecular pathology of acute myeloid leukemia.
Hematology. American Society of Hematology. Education Program - 1 Jan 2005
Licht Jonathan D, Sternberg David W
Abstract excerpt
The pathogenesis of acute myelogenous leukemia (AML) involves an array of molecular alterations that disrupt almost every facet of cell transformation. These processes include the regulation of cell proliferation, differentiation, self-renewal, survival, cell cycle checkpoint control, DNA repair and chromatin stability, and cell dissemination. Normal regulatory networks are disrupted or usurped by these...
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