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Article

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.

Blood - 15 Jan 2015

Stieglitz Elliot, Troup Camille B, Gelston Laura C, Haliburton John, Chow Eric D, Yu Kristie B, Akutagawa Jon, Taylor-Weiner Amaro N, Liu Y Lucy, Wang Yong-Dong, Beckman Kyle, Emanuel Peter D, Braun Benjamin S, Abate Adam, Gerbing Robert B, Alonzo Todd A, Loh Mignon L

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of childhood associated with a poor prognosis. Recently, massively parallel sequencing has identified recurrent mutations in the SKI domain of SETBP1 in a variety of myeloid disorders. These lesions were detected in nearly 10% of patients with JMML and have been characterized as secondary events. We hypothesized that rare...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25395418
DOI: 10.1182/blood-2014-09-601690
PMCID: PMC4296011

Genes

SETBP1
SKI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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