Article
Potential value of high-throughput single-cell DNA sequencing of Juvenile myelomonocytic leukemia: report of two cases.
NPJ systems biology and applications - 9 Sept 2023
Volchkov E V, Khozyainova A A, Gurzhikhanova M Kh, Larionova I V, Matveev V E, Evseev D A, Ignatova A K, Menyailo M E, Venyov D A, Vorobev R S, Semchenkova A A, Olshanskaya Yu V, Denisov E V, Maschan M A
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disease of early childhood that develops due to mutations in the genes of the RAS-signaling pathway. Next-generation high throughput sequencing (NGS) enables identification of various secondary molecular genetic events that can facilitate JMML progression and transformation into secondary acute myeloid leukemia (sAML). The methods of single-cell...
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