Article
Mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia: a report from the Italian AIEOP study group.
Oncotarget - 17 May 2016
Bresolin Silvia, De Filippi Paola, Vendemini Francesca, D'Alia Mirko, Zecca Marco, Meyer Lueder H, Danesino Cesare, Locatelli Franco, Masetti Riccardo, Basso Giuseppe, Te Kronnie Geertruy
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is a rare aggressive disease of early childhood. Driver mutations in the Ras signaling pathways are a key feature of JMML patients. Mutations in SETBP1 and JAK3 were recently identified in a subset of JMML patients characterized by poor prognosis and progression of disease. In this study, we report the results of a screening for mutations in SETBP1 and JAK3 of a cohort of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.