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Article

Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2015

Vardarajan Badri N, Schaid Daniel J, Reitz Christiane, Lantigua Rafael, Medrano Martin, Jiménez-Velázquez Ivonne Z, Lee Joseph H, Ghani Mahdi, Rogaeva Ekaterina, St George-Hyslop Peter, Mayeux Richard P

Abstract excerpt

BACKGROUND: Inbreeding can be associated with a modification of disease risk due to excess homozygosity of recessive alleles affecting a wide range of phenotypes. We estimated the inbreeding coefficient in Caribbean Hispanics and examined its effects on risk of late-onset Alzheimer disease. METHODS: The inbreeding coefficient was calculated in 3,392 subjects (1,451 late-onset Alzheimer disease patients and 1,941...

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PMID: 25394174
DOI: 10.1038/gim.2014.161
PMCID: PMC4430451

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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