Article
A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families.
JAMA - 14 Nov 2001
Athan E S, Williamson J, Ciappa A, Santana V, Romas S N, Lee J H, Rondon H, Lantigua R A, Medrano M, Torres M, Arawaka S, Rogaeva E, Song Y Q, Sato C, Kawarai T, Fafel K C, Boss M A, Seltzer W K, Stern Y, St George-Hyslop P, Tycko B, Mayeux R
Abstract excerpt
CONTEXT: Genetic determinants of Alzheimer disease (AD) have not been comprehensively examined in Caribbean Hispanics, a population in the United States in whom the frequency of AD is higher compared with non-Hispanic whites. OBJECTIVE: To identify variant alleles in genes related to familial early-onset AD among Caribbean Hispanics. DESIGN AND SETTING: Family-based case series conducted in 1998-2001 at an AD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.